EXHIBIT 16.1 [PricewaterhouseCoopers LLP Letterhead] March 30, 2005 Securities and Exchange Commission 450 Fifth Street, N.W. Washington, D.C. 20549 Commissioners: We have read the statements made by The Quigley Corporation (copy attached), which we understand will be filed with the Commission, pursuant to Regulation S-K Item 304, as part of the Company's Form 10-K report dated March 31, 2005. We agree with the statements concerning our Firm in such Form 10-K. Very truly yours, /s/ PricewaterhouseCoopers LLP